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Tramadol

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Why has my veterinarian prescribed this medicine?

Tramadol is a synthetic mu-receptor opiate agonist. It is used to relieve severe pain.

How do I give this medication?pills

"Medication may be given with or without food."
  • Give this medication to your pet as directed by your veterinarian. READ THE LABEL CAREFULLY.
  • Medication may be given with or without food.
  • Try to give this medication at about the same time each day.
  • DO NOT give the pet more medicine than directed and do not give more often than directed.
  • Try not to miss giving any doses.

What do I do if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

  • Keep this medicine out of reach of children.
  • Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight.
  • Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

What are the potential side effects?

  • Tramadol is well tolerated in dogs. Some sedation is expected and is normal.
  • Your pet may experience some stomach upset that may lead to vomiting, constipation, diarrhea and/or loss of appetite. If these symptoms persist, contact your veterinarian.
  • Other side effects may occur. If you notice anything unusual, contact your veterinarian.

Are there any possible drug interactions?

  • Make sure to tell your veterinarian what other medication you are giving to your pet.
  • Quite often, your veterinarian may prescribe two different medications, and sometimes a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
  • The following drugs can potentially interact with tramadol: fluoxetine, monoamine oxidase inhibitors (i.e., selegiline, isoniazid), SAMe, amitriptyline, digoxin, and warfarin.
  • Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jul 28, 2016.